PXD001215
PXD001215 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Role of 14-3-3ζ in the adipogenesis program and the differentiation of healthy adipose tissue |
Description | Obesity is an independent risk factor for diabetes and cardiovascular disease. Before effective anti-obesity therapies can be developed, understanding of what governs the production of healthy versus unhealthy fat tissue is required, as not all types confer equal risk. Adipogenesis requires the precise transduction of signals and coordination of transcription factor cascades. Molecular adaptor proteins of the 14-3-3 family are known to coordinate signaling events from multiple cues, but whether specific isoforms have unique, non-redundant roles in adipogenesis remains unclear. RNAi screening revealed 14-3-3ζ as the critical isoform for in vitro adipocyte differentiation. This study aims to understand the role of 14-3-3ζ in adipogenesis program and the differentiation in health adipose tissue. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-03 |
AnnouncementXML | Submission_2024-10-03_08:37:32.608.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD001215 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Neng Fang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | Oxidation; Carbamidomethyl |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2014-08-08 03:26:53 | ID requested | |
⏵ 1 | 2024-10-03 08:37:33 | announced |
Publication List
10.6019/PXD001215; |
10.1074/jbc.m117.816272; |
Mugabo Y, Sadeghi M, Fang NN, Mayor T, Lim GE, interactome reveals critical roles of RNA-splicing factors during adipogenesis. J Biol Chem, 293(18):6736-6750(2018) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: 14-3-3, adipogenesis, adipocytes, differentiation, molecular adaptors |
Contact List
Thibault Mayor | |
---|---|
contact affiliation | Center of High-throughput Biology, Dept. of Biochemistry and Molecular Biology, UBC |
contact email | mayor@mail.ubc.ca |
lab head | |
Neng Fang | |
contact affiliation | Centre for High Throughput Biology |
contact email | nengf@interchange.ubc.ca |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD001215 |
PRIDE project URI |
Repository Record List
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