PXD001215

PXD001215 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Role of 14-3-3ζ in the adipogenesis program and the differentiation of healthy adipose tissue
Description	Obesity is an independent risk factor for diabetes and cardiovascular disease. Before effective anti-obesity therapies can be developed, understanding of what governs the production of healthy versus unhealthy fat tissue is required, as not all types confer equal risk. Adipogenesis requires the precise transduction of signals and coordination of transcription factor cascades. Molecular adaptor proteins of the 14-3-3 family are known to coordinate signaling events from multiple cues, but whether specific isoforms have unique, non-redundant roles in adipogenesis remains unclear. RNAi screening revealed 14-3-3ζ as the critical isoform for in vitro adipocyte differentiation. This study aims to understand the role of 14-3-3ζ in adipogenesis program and the differentiation in health adipose tissue.
HostingRepository	PRIDE
AnnounceDate	2024-10-03
AnnouncementXML	Submission_2024-10-03_08:37:32.608.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD001215
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Neng Fang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2014-08-08 03:26:53	ID requested
⏵ 1	2024-10-03 08:37:33	announced

Publication List

10.6019/PXD001215;
10.1074/jbc.m117.816272;
Mugabo Y, Sadeghi M, Fang NN, Mayor T, Lim GE, interactome reveals critical roles of RNA-splicing factors during adipogenesis. J Biol Chem, 293(18):6736-6750(2018) [pubmed]

10.6019/PXD001215;

10.1074/jbc.m117.816272;

Mugabo Y, Sadeghi M, Fang NN, Mayor T, Lim GE, interactome reveals critical roles of RNA-splicing factors during adipogenesis. J Biol Chem, 293(18):6736-6750(2018) [pubmed]

Keyword List

curator keyword: Biological, Biomedical
submitter keyword: 14-3-3, adipogenesis, adipocytes, differentiation, molecular adaptors

curator keyword: Biological, Biomedical

submitter keyword: 14-3-3, adipogenesis, adipocytes, differentiation, molecular adaptors

Contact List

Thibault Mayor
contact affiliation	Center of High-throughput Biology, Dept. of Biochemistry and Molecular Biology, UBC
contact email	mayor@mail.ubc.ca
lab head
Neng Fang
contact affiliation	Centre for High Throughput Biology
contact email	nengf@interchange.ubc.ca
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD001215

PRIDE project URI

Repository Record List

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