PXD001124

PXD001124 is an original dataset announced via ProteomeXchange.

Title	Tissue proteomics of splenic marginal zone lymphoma
Description	Splenic marginal zone lymphoma (SMZL) is a rare chronic B lymphoproliferative disease, whose molecular pathogenesis is still not well established. For the first time a proteomic approach was undertaken to analyse the protein profiles of SMZL tissue. Western blot, immunohistochemical analysis and functional data mining were also performed in order to validate results, classify proteins, and explore their potential relationships. We demonstrated that SMZL is characterized by modulation of proteins related to energetic metabolism and apoptosis pathways. We also reported specific proteins (such as biliverdin reductase A, manganese superoxide dismutase, beta-2 microglobulin, growth factor receptor-bound protein 2, acidic leucine-rich nuclear phosphoprotein 32 family member A, and SET nuclear oncogene) directly involved in NF-kBand BCR pathways, as well as in chromatin remodelling and cytoskeleton. Our findings shed new light on SMZL pathogenesis and provide a basis for the future development of novel biomarkers.
HostingRepository	PRIDE
AnnounceDate	2015-04-23
AnnouncementXML	Submission_2015-04-23_02:23:07.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD001124
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Daniela Cecconi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue; L-homoarginine
Instrument	ion trap

Revision	Datetime	Status	ChangeLog Entry
0	2014-07-10 06:49:51	ID requested
⏵ 1	2015-04-23 02:23:09	announced

Polati R, Brandi J, Dalai I, Zam, ò A, Cecconi D, Tissue proteomics of splenic marginal zone lymphoma. Electrophoresis, 36(14):1612-21(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: splenic marginal zone lymphoma, tissue proteomics, lymphocytes

Daniela Cecconi
contact affiliation	Mass Spectrometry & Proteomics Lab Department of Biotechnology, University of Verona Strada le Grazie 15, 37134 Verona, Italy
contact email	daniela.cecconi@univr.it
lab head
Daniela Cecconi
contact affiliation	Department of Biotechnology
contact email	daniela.cecconi@univr.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/04/PXD001124

PRIDE project URI

• PRIDE
  1. PXD001124
     1. Label: PRIDE project
     2. Name: Tissue proteomics of splenic marginal zone lymphoma