PXD001110

PXD001110 is an original dataset announced via ProteomeXchange.

Title	The role of PRDX1 in chemoresistance
Description	The role of peroxiredoxin 1 in confering chemoresistance in glioma was analysed in a cell culture system. Cells with a lower level of peroxiredoxin 1 showed a higher level of reacitve oxigen species upon treatment with BCNU. In line with this, in a 2D DIGE based redox proteomics approach, proteins were identified showing (1) differences in their thiol state upon knockdown of PRDX1 and (2) proteins showing differences in reduded and unreduced samples.
HostingRepository	PRIDE
AnnounceDate	2014-12-12
AnnouncementXML	Submission_2014-12-12_03:45:53.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD001110
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Gereon Poschmann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidoethyl-L-cysteine; monohydroxylated residue; acetylated residue
Instrument	HCTultra

Revision	Datetime	Status	ChangeLog Entry
0	2014-07-04 07:32:47	ID requested
⏵ 1	2014-12-12 03:45:54	announced

Poschmann G, Grzendowski M, Stefanski A, Bruns E, Meyer HE, St, ü, hler K, Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress. Biochim Biophys Acta, 1854(6):624-31(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: PRDX1, redox proteomics, glioma, chemoresistance

Gereon Poschmann
contact affiliation	Molecular Proteomics Laboratory, Düsseldorf, HHU
contact email	gereon.poschmann@hhu.de
lab head
Gereon Poschmann
contact affiliation	Medizin
contact email	gereon.poschmann@rub.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD001110
     1. Label: PRIDE project
     2. Name: The role of PRDX1 in chemoresistance