PXD001062

PXD001062 is an original dataset announced via ProteomeXchange.

Title	Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase
Description	We inhibited the proteosome to ‘trap’ ubiquitylated substrates on the SCFFBXW11 E3 complex. Comparative mass spectrometry analysis of immunopurified FBXW11 protein complexes before and after proteosome inhibition revealed known and putatively novel substrates.
HostingRepository	PRIDE
AnnounceDate	2014-10-24
AnnouncementXML	Submission_2014-10-24_02:49:32.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dennis Goldfarb
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; phosphorylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2014-06-13 09:15:19	ID requested
⏵ 1	2014-10-24 02:49:33	announced

Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB, TrCP2/FBXW11 ubiquitin ligase. Mol Cell Biol, 35(1):167-81(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: FBXW11, BTRC, E3 Ubiquitin Ligase

Michael Ben Major
contact affiliation	Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
contact email	ben_major@med.unc.edu
lab head
Dennis Goldfarb
contact affiliation	Cell and Developmental Biology
contact email	dennisg@email.unc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/10/PXD001062

PRIDE project URI

• PRIDE
  1. PXD001062
     1. Label: PRIDE project
     2. Name: Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase