PXD001052

PXD001052 is an original dataset announced via ProteomeXchange.

Title	Non-Small Cell Lung Cancer patients undergoing radical radiotherapy
Description	Currently there is no predictive marker with clinical utility to guide treatment decisions in NSCLC patients undergoing radiotherapy. Identification of such markers would allow treatment options to be considered for more effective therapy. To enable the identification of appropriate protein biomarkers, plasma samples were collected from patients with non-small cell lung cancer before and during radiotherapy for longitudinal comparison following a protocol that carries sufficient power for effective discovery proteomics. Plasma samples from patients pre- and during radiotherapy who had survived >18 months were compared to the same time points from patients who survived <14 months using an 8 channel isobaric tagging tandem mass spectrometry discovery proteomics platform.
HostingRepository	PRIDE
AnnounceDate	2018-10-19
AnnouncementXML	Submission_2018-10-19_00:08:33.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Walker
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2014-06-11 01:49:31	ID requested
⏵ 1	2018-10-19 00:08:35	announced

Walker MJ, Zhou C, Backen A, Pernemalm M, Williamson AJ, Priest LJ, Koh P, Faivre-Finn C, Blackhall FH, Dive C, Whetton AD, Discovery and Validation of Predictive Biomarkers of Survival for Non-small Cell Lung Cancer Patients Undergoing Radical Radiotherapy: Two Proteins With Predictive Value. EBioMedicine, 2(8):841-50(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: Plasma LC-MS Lung Cancer iTRAQ

Anthony Whetton
contact affiliation	Institute of Cancer Sciences 1st floor, Wolfson Molecuar Imaging Centre 27 Palatine Road Withington Manchester M20 3LJ
contact email	Tony.Whetton@manchester.ac.uk
lab head
Michael Walker
contact affiliation	University of Manchester
contact email	mwalker@picr.man.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD001052

PRIDE project URI

• PRIDE
  1. PXD001052
     1. Label: PRIDE project
     2. Name: Non-Small Cell Lung Cancer patients undergoing radical radiotherapy