PXD001026 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Systematic evaluation of quantotypic peptides for targeted analysis of the human kinome |
Description | In targeted proteomics it is critical that peptides are not only proteotypic, but also accurately represent the level of the protein (quantotypic). Numerous approaches are used to identify proteotypic peptides, but quantotypic properties are rarely assessed. Here, we show that measuring ratios of proteotypic peptides across biological samples can be used to empirically identify peptides with good quantotypic properties, and use this to identify quantotypic peptides for 21% of the human kinome. |
HostingRepository | PRIDE |
AnnounceDate | 2014-08-08 |
AnnouncementXML | Submission_2014-09-25_03:38:24.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Jonathan Worboys |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | deamidated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos; TSQ Vantage |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2014-06-02 03:28:42 | ID requested | |
1 | 2014-08-08 08:33:03 | announced | |
⏵ 2 | 2014-09-25 03:38:25 | announced | Updated publication reference for PubMed record(s): 25152083. |
Publication List
Worboys JD, Sinclair J, Yuan Y, J, ø, rgensen C, Systematic evaluation of quantotypic peptides for targeted analysis of the human kinome. Nat Methods, 11(10):1041-4(2014) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: SRM, Bioinformatics, Quantotypic |
Contact List
Claus Jørgensen |
contact affiliation | CRUK Manchester Institute |
contact email | Claus.Jorgensen@cruk.manchester.ac.uk |
lab head | |
Jonathan Worboys |
contact affiliation | CRUK MI, ICR |
contact email | jonathan.worboys@cruk.manchester.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/08/PXD001026 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001026
- Label: PRIDE project
- Name: Systematic evaluation of quantotypic peptides for targeted analysis of the human kinome