PXD000958

PXD000958 is an original dataset announced via ProteomeXchange.

Title	Silencing RNA-binding protein CELF1 inhibits tumor growth and alters gene expression in oral squamous cell carcinoma
Description	RNA-binding proteins (RBPs) are important regulators of gene expression, but few have been studied for their role in malignancy. Using proteo-genomic techniques, we have identified the RBP CELF1 mRNA alternative splicing, translation and turnover targets in oral cancer cells. SILAC and Mass spectrometry analysis, identified 1322 proteins translationally controlled by CELF1 and many of these altered proteins were implicated in malignancy. Our genomic and proteomic analyses provided a comprehensive view of the CELF1 mRNA regulatory network in oral cancer and suggests that CELF1 is a viable target for therapeutic intervention.
HostingRepository	PRIDE
AnnounceDate	2022-02-28
AnnouncementXML	Submission_2022-02-28_03:06:31.858.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Viswanathan Palanisamy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2014-05-08 01:26:13	ID requested
⏵ 1	2022-02-28 03:06:32	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Oral squamous cell carcinoma, CELF1, RNA-binding protein and mRNA translation, SILAC, LC-MS/MS

Viswanathan Palanisamy
contact affiliation	College of Dental Medicine, Oral Health Sciences, Medical Univeristy of South Carolina, USA
contact email	visu@musc.edu
lab head
Viswanathan Palanisamy
contact affiliation	Medical University of South Carolina
contact email	visu@musc.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD000958
     1. Label: PRIDE project
     2. Name: Silencing RNA-binding protein CELF1 inhibits tumor growth and alters gene expression in oral squamous cell carcinoma