PXD000859

PXD000859 is an original dataset announced via ProteomeXchange.

Title	Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
Description	Type 1 and type 2 diabetes (T1D and T2D) share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, while beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alter the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates. The same transcriptional relationships were observed in human islets, demonstrating the role for beta cell fragility in genetic predisposition to diabetes.
HostingRepository	PRIDE
AnnounceDate	2016-02-24
AnnouncementXML	Submission_2016-05-02_03:07:03.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD000859
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jonathan Vandenbussche
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	propanoyl labeling reagent heavy form (+3amu) (K): 59.036279; 2-pyrrolidone-5-carboxylic acid (Gln): -17.026549; L-methionine (S)-sulfoxide: 15.994915; N-acetylated residue: 42.010565; propanoyl labeling reagent light form (N-term): 56.026215; N6-propanoyl-L-lysine: 56.026215
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2014-03-27 01:41:13	ID requested
1	2016-02-24 04:48:22	announced
⏵ 2	2016-05-02 03:07:04	announced	Updated publication reference for PubMed record(s): 26998692.

Dooley J, Tian L, Schonefeldt S, Delghingaro-Augusto V, Garcia-Perez JE, Pasciuto E, Di Marino D, Carr EJ, Oskolkov N, Lyssenko V, Franckaert D, Lagou V, Overbergh L, Vandenbussche J, Allemeersch J, Chabot-Roy G, Dahlstrom JE, Laybutt DR, Petrovsky N, Socha L, Gevaert K, Jetten AM, Lambrechts D, Linterman MA, Goodnow CC, Nolan CJ, Lesage S, Schlenner SM, Liston A, Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes. Nat Genet, 48(5):519-27(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: diabetes, B10 mice, NOD mice, insHEL

Kris Gevaert
contact affiliation	University Ghent, VIB
contact email	kris.gevaert@vib-ugent.be
lab head
Jonathan Vandenbussche
contact affiliation	Biochemistry
contact email	jonathan.vandenbussche@vib-ugent.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD000859

PRIDE project URI

• PRIDE
  1. PXD000859
     1. Label: PRIDE project
     2. Name: Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes