PXD000795

PXD000795 is an original dataset announced via ProteomeXchange.

Title	Identification of full length Hsp90 from Giardia lamblia cell lysate
Description	In the present study using mass-spectrometry we identify the sequence of the unique, junctional peptide contributed by the 5’ UTR of HspC ORF in the full length Hsp90 from Giardia lamblia. This peptide is critical for the catalytic function of Hsp90 as it harbours an essential “Arg” homolog in its sequence. We also show that full length GlHsp90 possesses all the functional hall marks of a canonical Hsp90 including its ability to bind and hydrolyze ATP.
HostingRepository	PRIDE
AnnounceDate	2016-07-09
AnnouncementXML	Submission_2016-07-08_19:23:23.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Utpal Tatu
SpeciesList	scientific name: Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia); NCBI TaxID: 184922;
ModificationList	iodoacetamide derivatized residue
Instrument	QSTAR

Revision	Datetime	Status	ChangeLog Entry
0	2014-03-05 03:02:03	ID requested
⏵ 1	2016-07-08 19:23:24	announced

Nageshan RK, Roy N, Ranade S, Tatu U, Trans-spliced heat shock protein 90 modulates encystation in Giardia lamblia. PLoS Negl Trop Dis, 8(5):e2829(2014) [pubmed]

submitter keyword: Hsp90, Giardia lamblia, trans-splicing, junctional peptide, molecular chaperones, ATPase activity

Prof. Utpal Tatu
contact affiliation	Department of Biochemistry, Indian Institute of Science, Bangalore - 560 012 India
contact email	tatu@biochem.iisc.ernet.in
lab head
Utpal Tatu
contact affiliation	Dept. of Biochemistry, Indian Institute of Science, Bangalore, India
contact email	tatu@biochem.iisc.ernet.in
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD000795
     1. Label: PRIDE project
     2. Name: Identification of full length Hsp90 from Giardia lamblia cell lysate