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PXD000795

PXD000795 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of full length Hsp90 from Giardia lamblia cell lysate
DescriptionIn the present study using mass-spectrometry we identify the sequence of the unique, junctional peptide contributed by the 5’ UTR of HspC ORF in the full length Hsp90 from Giardia lamblia. This peptide is critical for the catalytic function of Hsp90 as it harbours an essential “Arg” homolog in its sequence. We also show that full length GlHsp90 possesses all the functional hall marks of a canonical Hsp90 including its ability to bind and hydrolyze ATP.
HostingRepositoryPRIDE
AnnounceDate2016-07-09
AnnouncementXMLSubmission_2016-07-08_19:23:23.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterUtpal Tatu
SpeciesList scientific name: Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia); NCBI TaxID: 184922;
ModificationListiodoacetamide derivatized residue
InstrumentQSTAR
Dataset History
RevisionDatetimeStatusChangeLog Entry
02014-03-05 03:02:03ID requested
12016-07-08 19:23:24announced
Publication List
Nageshan RK, Roy N, Ranade S, Tatu U, Trans-spliced heat shock protein 90 modulates encystation in Giardia lamblia. PLoS Negl Trop Dis, 8(5):e2829(2014) [pubmed]
Keyword List
submitter keyword: Hsp90, Giardia lamblia, trans-splicing, junctional peptide, molecular chaperones, ATPase activity
Contact List
Prof. Utpal Tatu
contact affiliationDepartment of Biochemistry, Indian Institute of Science, Bangalore - 560 012 India
contact emailtatu@biochem.iisc.ernet.in
lab head
Utpal Tatu
contact affiliationDept. of Biochemistry, Indian Institute of Science, Bangalore, India
contact emailtatu@biochem.iisc.ernet.in
dataset submitter
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Dataset FTP location
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PRIDE project URI
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