PXD000786 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | BMP1/Tolloid-like substrates by iTRAQ degradomics |
Description | In this study, we used an iTRAQ-based quantitative proteomic approach to reveal the release of proteolytic fragments from the cell surface or the ECM by BMP-1. Thirty-seven extracellular proteins were found in significantly higher or lower amounts in the conditioned medium of HT1080 cells overexpressing BMP-1 and thus, could be considered as candidate substrates. Strikingly, three of these new candidates (betaglycan, CD109 and neuropilin-1) were TGF-Beta co-receptors, also acting as antagonists when released from the cell surface, and were chosen for further substrate validation. |
HostingRepository | PRIDE |
AnnounceDate | 2014-09-30 |
AnnouncementXML | Submission_2014-09-30_00:30:18.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD000786 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Frederic DELOLME |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | deamidated residue; monohydroxylated residue; acetylated residue; iTRAQ4plex-116 reporter+balance reagent acylated residue; methylthiolated residue |
Instrument | QSTAR |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2014-03-03 08:42:50 | ID requested | |
1 | 2014-09-29 02:28:47 | announced | |
⏵ 2 | 2014-09-30 00:30:20 | announced | Updated project metadata. |
Publication List
Delolme F, Anastasi C, Alcaraz LB, Mendoza V, Vadon-Le Goff S, Talantikite M, Capomaccio R, Mevaere J, Fortin L, Mazzocut D, Damour O, Zanella-Cl, é, on I, Hulmes DJ, Overall CM, Valcourt U, Lopez-Casillas F, Moali C, co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics. Cell Mol Life Sci, 72(5):1009-27(2015) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: TFG-Beta, BMP-1, protease, iTRAQ, iTRAQ-ATOMS |
Contact List
Frederic Delolme |
contact affiliation | IBCP-CCMP, CNRS, LYON France |
contact email | frederic.delolme@ibcp.fr |
lab head | |
Frederic DELOLME |
contact affiliation | CNRS-IBCP |
contact email | frederic.delolme@ibcp.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/09/PXD000786 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD000786
- Label: PRIDE project
- Name: BMP1/Tolloid-like substrates by iTRAQ degradomics