PXD000769 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Colon cancer stem cell over-expressing Np63α |
Description | p63, a member of p53 family, is transcribed in different variants, containing (TA) or lacking (N) the N-terminal transactivation domain. Although the proteins of p53 family share high sequence and structural similarities, distinct functions for p63 are emerging. Here we provided a quantitative proteomic analysis by stable isotope dimethyl labeling of colon cancer stem cells over-expressing Np63α in order to investigate the cellular pathways modulated by this p63 isoform. |
HostingRepository | PRIDE |
AnnounceDate | 2014-03-17 |
AnnouncementXML | Submission_2014-03-17_07:13:13.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD000769 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Simona D'Aguanno |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; 2x(13)C: 6x(2)H labeled dimethylated L-arginine; dihydroxylated residue; formylated residue |
Instrument | micrOTOF II |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2014-02-20 03:19:41 | ID requested | |
⏵ 1 | 2014-03-17 07:13:14 | announced | |
Publication List
D'Aguanno S, Barcaroli D, Rossi C, Zucchelli M, Ciavardelli D, Cortese C, De Cola A, Volpe S, D'Agostino D, Todaro M, Stassi G, Di Ilio C, Urbani A, De Laurenzi V, p63 isoforms regulate metabolism of cancer stem cells. J Proteome Res, 13(4):2120-36(2014) [pubmed] |
Keyword List
submitter keyword: p63, colon cancer stem cells, stable isotope dimethyl labeling, LC-MSMS |
Contact List
Prof. Andrea Urbani |
contact affiliation | Department of Experimental Medicine, University of Tor Vergata, Rome, Italy |
contact email | andrea.urbani@uniroma2.it |
lab head | |
Simona D'Aguanno |
contact affiliation | Experimental Chemotherapy Laboratory Regina Elena National Cancer Institute, Rome, Italy |
contact email | simonadaguanno@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD000769
- Label: PRIDE project
- Name: Colon cancer stem cell over-expressing Np63α