PXD000768

PXD000768 is an original dataset announced via ProteomeXchange.

Title	Colon cancer stem cell over-expressing TAp63α
Description	p63, a member of p53 family, is transcribed in different variants, containing (TA) or lacking (N) the N-terminal transactivation domain. Although the proteins of p53 family share high sequence and structural similarities, distinct functions for p63 are emerging. Here we provided a quantitative proteomic analysis by stable isotope dimethyl labeling of colon cancer stem cells over-expressing TAp63α in order to investigate the cellular pathways modulated by this p63 isoform.
HostingRepository	PRIDE
AnnounceDate	2014-07-24
AnnouncementXML	Submission_2014-07-24_03:55:50.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD000768
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Simona D'Aguanno
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; 2x(13)C: 6x(2)H labeled dimethylated L-arginine; dihydroxylated residue; formylated residue
Instrument	micrOTOF II

Revision	Datetime	Status	ChangeLog Entry
0	2014-02-20 03:18:56	ID requested
1	2014-03-17 07:07:07	announced
⏵ 2	2014-07-24 03:55:51	announced	Updated project metadata.

D'Aguanno S, Barcaroli D, Rossi C, Zucchelli M, Ciavardelli D, Cortese C, De Cola A, Volpe S, D'Agostino D, Todaro M, Stassi G, Di Ilio C, Urbani A, De Laurenzi V, p63 isoforms regulate metabolism of cancer stem cells. J Proteome Res, 13(4):2120-36(2014) [pubmed]

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

curator keyword: Biomedical

submitter keyword: p63, colon cancer stem cells, stable isotope dimethyl labeling, LC-MSMS

Prof. Andrea Urbani
contact affiliation	Department of Experimental Medicine, University of Tor Vergata, Rome, Italy
contact email	andrea.urbani@uniroma2.it
lab head
Simona D'Aguanno
contact affiliation	Experimental Chemotherapy Laboratory Regina Elena National Cancer Institute, Rome, Italy
contact email	simonadaguanno@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/03/PXD000768

PRIDE project URI

• PRIDE
  1. PXD000768
     1. Label: PRIDE project
     2. Name: Colon cancer stem cell over-expressing TAp63α