<<< Full experiment listing

PXD000766

PXD000766 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePlasma protein corona on superparamagnetic iron oxide nanoparticles (SPIONs)
DescriptionWe determined the composition of the plasma protein corona on silica-coated versus dextran-coated iron oxide nanoparticles using mass spectrometry-based proteomics approaches. Gene ontology (GO) enrichment analysis and Ingenuity Pathway Analysis (IPA) revealed distinct protein corona compositions for the two different SPIONs. Relaxivity of silica-coated SPIONs was modulated by the presence of a protein corona. Moreover, the viability of primary human monocyte-derived macrophages was influenced by the protein corona on silica-coated, but not dextran-coated SPIONs, and the protein corona promoted cellular uptake of silica-coated SPIONs, but did not affect internalization of dextran-coated SPIONs.
HostingRepositoryPRIDE
AnnounceDate2015-10-12
AnnouncementXMLSubmission_2015-10-12_04:49:11.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMaria Pernemalm
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02014-02-19 07:37:51ID requested
12015-10-12 04:49:12announced
Publication List
Vogt C, Pernemalm M, Kohonen P, Laurent S, Hultenby K, Vahter M, Lehti, ö J, Toprak MS, Fadeel B, Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages. PLoS One, 10(10):e0129008(2015) [pubmed]
Keyword List
submitter keyword: nanoparticles, macrophages, protein corona, mass spectrometry, superparamagnetic
Contact List
Janne Lehtiö
contact affiliationDept. of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Clinical proteomics mass spectrometry, Science for Life Laboratory, Sweden
contact emailjanne.lehtio@ki.se
lab head
Maria Pernemalm
contact affiliationClinical Proteomics Unit, Dep. of Oncology-Pathology
contact emailmaria.pernemalm@ki.se
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/10/PXD000766
PRIDE project URI
Repository Record List
[ + ]