PXD000766 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Plasma protein corona on superparamagnetic iron oxide nanoparticles (SPIONs) |
Description | We determined the composition of the plasma protein corona on silica-coated versus dextran-coated iron oxide nanoparticles using mass spectrometry-based proteomics approaches. Gene ontology (GO) enrichment analysis and Ingenuity Pathway Analysis (IPA) revealed distinct protein corona compositions for the two different SPIONs. Relaxivity of silica-coated SPIONs was modulated by the presence of a protein corona. Moreover, the viability of primary human monocyte-derived macrophages was influenced by the protein corona on silica-coated, but not dextran-coated SPIONs, and the protein corona promoted cellular uptake of silica-coated SPIONs, but did not affect internalization of dextran-coated SPIONs. |
HostingRepository | PRIDE |
AnnounceDate | 2015-10-12 |
AnnouncementXML | Submission_2015-10-12_04:49:11.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Maria Pernemalm |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2014-02-19 07:37:51 | ID requested | |
⏵ 1 | 2015-10-12 04:49:12 | announced | |
Publication List
Vogt C, Pernemalm M, Kohonen P, Laurent S, Hultenby K, Vahter M, Lehti, ö J, Toprak MS, Fadeel B, Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages. PLoS One, 10(10):e0129008(2015) [pubmed] |
Keyword List
submitter keyword: nanoparticles, macrophages, protein corona, mass spectrometry, superparamagnetic |
Contact List
Janne Lehtiö |
contact affiliation | Dept. of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Clinical proteomics mass spectrometry, Science for Life Laboratory, Sweden |
contact email | janne.lehtio@ki.se |
lab head | |
Maria Pernemalm |
contact affiliation | Clinical Proteomics Unit, Dep. of Oncology-Pathology |
contact email | maria.pernemalm@ki.se |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/10/PXD000766 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD000766
- Label: PRIDE project
- Name: Plasma protein corona on superparamagnetic iron oxide nanoparticles (SPIONs)