PXD000719

PXD000719 is an original dataset announced via ProteomeXchange.

Title	Rat Brain LC-MS/MS
Description	Voltage-gated sodium channels are responsible for the initiation and propagation of action potentials in excitable cells. While the channel is functional on its own, it is the transient and stable protein-protein interactions that modulate functional outcomes. AP-MS has been successfully applied to a number of ion channels. However to the best of our knowledge, no AP-MS study has been carried out on any member of the voltage-gated sodium channel family.
HostingRepository	PRIDE
AnnounceDate	2015-03-20
AnnouncementXML	Submission_2015-03-20_01:33:16.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Norelle Wildburger
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; phosphorylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2014-01-29 03:29:34	ID requested
1	2015-03-03 08:41:49	announced
⏵ 2	2015-03-20 01:33:17	announced	Updated project metadata.

Wildburger NC, Ali SR, Hsu WC, Shavkunov AS, Nenov MN, Lichti CF, LeDuc RD, Mostovenko E, Panova-Elektronova NI, Emmett MR, Nilsson CL, Laezza F, Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain. Mol Cell Proteomics, 14(5):1288-300(2015) [pubmed]

curator keyword: Biomedical, Biological

submitter keyword: Mammalian Brain, AP-MS, Interactome

Carol Lynn Nilsson
contact affiliation	Department of Pharmacology & Toxicology
contact email	clnilsso@utmb.edu
lab head
Norelle Wildburger
contact affiliation	Department of Pharmacology and Toxicology
contact email	wildburger@msn.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/03/PXD000719

PRIDE project URI

• PRIDE
  1. PXD000719
     1. Label: PRIDE project
     2. Name: Rat Brain LC-MS/MS