PXD000690

PXD000690 is an original dataset announced via ProteomeXchange.

Title	Altered microbiota-host mutualism and bloom of Atopobium define severe pediatric Crohn's disease
Description	Microbial dysbiosis has been identified in adult inflammatory bowel disease (IBD) patients. However, microbial composition and functional interplay between host genetics and microorganisms in early IBD onset remain poorly defined. Here, we identified and demonstrated the causal effect of Atopobium parvulum and the gut microbiota in pediatric IBD. Microbiota and proteomic profiling revealed that the abundance of A. parvulum, a potent H2S producer, was associated with increased disease severity and a concurrent reduction in the expression of the host H2S detoxification pathway. In the Il10-/- mouse model of inflammation, A. parvulum induced severe pancolitis that was dependent on the presence of the gut microbiota. In addition, we demonstrated that administration of bismuth, an H2S scavenger, prevented A. parvulum-induced colitis. Our findings identified Atopobium parvulum as a major mediator of inflammation severity, and revealed an alteration of the balance between the production and detoxification of H2S in the gastrointestinal tract.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:33:19.443.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Amanda Starr
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2014-01-20 02:01:33	ID requested
1	2022-02-22 03:53:47	announced
⏵ 2	2024-10-22 05:33:26	announced	2024-10-22: Updated project metadata.

10.1038/ncomms13419;

Mottawea W, Chiang CK, M, ü, hlbauer M, Starr AE, Butcher J, Abujamel T, Deeke SA, Brandel A, Zhou H, Shokralla S, Hajibabaei M, Singleton R, Benchimol EI, Jobin C, Mack DR, Figeys D, Stintzi A, Altered intestinal microbiota-host mitochondria crosstalk in new onset Crohn's disease. Nat Commun, 7():13419(2016) [pubmed]

submitter keyword: IBD,colon

Daniel Figeys
contact affiliation	Department of Biochemistry, Microbiology and Immunology Institute of Systems Biology University of Ottawa
contact email	dfigeys@uottawa.ca
lab head
Amanda Starr
contact affiliation	University of Ottawa
contact email	amanda.e.starr@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD000690

PRIDE project URI

• PRIDE
  1. PXD000690
     1. Label: PRIDE project
     2. Name: Altered microbiota-host mutualism and bloom of Atopobium define severe pediatric Crohn's disease