PXD000670

PXD000670 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as new regulators of cytosolic dsRNA-induced innate immune response
Description	In this study, we have used global phosphoproteomic analysis to define phosphorylation-dependent signaling events regulated during RLR stimulation in human keratinocytes. In addition, we used quantitative 14-3-3-affinity capture to identify major target molecules of 14-3-3 regulation.
HostingRepository	PRIDE
AnnounceDate	2014-07-24
AnnouncementXML	Submission_2014-07-24_03:48:22.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tuula Nyman
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; phosphorylated residue
Instrument	QSTAR

Revision	Datetime	Status	ChangeLog Entry
0	2014-01-08 01:52:24	ID requested
1	2014-07-08 07:06:28	announced
⏵ 2	2014-07-24 03:48:23	announced	Updated project metadata.

Ö, hman T, S, ö, derholm S, Hintsanen P, V, ä, lim, ä, ki E, Lietz, é, n N, MacKintosh C, Aittokallio T, Matikainen S, Nyman TA, Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway. Mol Cell Proteomics, 13(10):2604-17(2014) [pubmed]

curator keyword: Biomedical

submitter keyword: Human keratinocytes, phosphorylation, LC-MS\MS

Tuula Nyman
contact affiliation	Institute of Biotechnology, University of Helsinki
contact email	tuula.nyman@helsinki.fi
lab head
Tuula Nyman
contact affiliation	Institute of Biotechnology
contact email	tuula.nyman@helsinki.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/07/PXD000670

PRIDE project URI

• PRIDE
  1. PXD000670
     1. Label: PRIDE project
     2. Name: Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as new regulators of cytosolic dsRNA-induced innate immune response