PXD000582

PXD000582 is an original dataset announced via ProteomeXchange.

Title	Discovery of plasma/serum protein biomarkers for progression from Mycobacterium tuberculosis infection to disease
Description	The overall scope of this study is to find early tuberculosis (TB) candidate protein biomarkers in different TB study groups vs. controls. The identified biomarkers may become the basis of a rapid diagnostic test able to identify active TB earlier than current practice. In addition, the candidate biomarkers may predict which patients are likely to convert from latent infection to active disease. . This project uses plasma and serum samples collected in a long-standing TB household contact study, the Kawempe Community Health Study, conducted in Kampala, Uganda, a TB endemic area. The study utilizes samples from TB index cases and household contacts that were negative for TB at recruitment. A subset of these contacts developed Mtb infection (i.e., their Tuberculin Skin Test (TST) converted to positive) after 3-6 months, and smaller subset developed active TB after 3 months of follow-up. Control patients were still TST negative at 12 months or 24 months of follow-up. This dataset corresponds to the discovery phase of the study.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:59:25.138.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eustache Paramithiotis
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetaldehyde crosslinked penta-L-lysine; 2-pyrrolidone-5-carboxylic acid (Gln); monohydroxylated residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2013-11-14 05:47:05	ID requested
1	2019-11-25 04:58:26	announced
2	2019-11-27 06:54:18	announced	2019-11-27: Updated project metadata.
⏵ 3	2024-10-22 04:59:33	announced	2024-10-22: Updated project metadata.

Bark CM, Manceur AM, Malone LL, Nsereko M, Okware B, Mayanja HK, Joloba ML, Rajotte I, Mentinova M, Kay P, Lo S, Tremblay P, Stein CM, Boom WH, Paramithiotis E, Identification of Host Proteins Predictive of Early Stage Mycobacterium tuberculosis Infection. EBioMedicine, 21():150-157(2017) [pubmed]

10.1016/j.ebiom.2017.06.019;

curator keyword: Biomedical

submitter keyword: disease progression, tuberculosis,discovery, early detection, biomarker, serum/plasma

Eustache Paramithiotis
contact affiliation	Caprion Biosciences, 201 President-Kennedy Ave., Montreal, H2X 3Y7, Quebec, Canada
contact email	eparamithiotis@caprion.com
lab head
Eustache Paramithiotis
contact affiliation	Caprion Biosciences Inc.
contact email	eparamithiotis@caprion.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/11/PXD000582

PRIDE project URI

• PRIDE
  1. PXD000582
     1. Label: PRIDE project
     2. Name: Discovery of plasma/serum protein biomarkers for progression from Mycobacterium tuberculosis infection to disease