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PXD000561

DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2014-07-24
  • AnnouncementXML: Submission_2014-07-24_03:56:37.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • Reprocessed datasets that are derived from this dataset: RPXD006668
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Akhilesh Pandey
  • Title: A draft map of the human proteome
  • Description: The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here, we report a draft map of the human proteome based on high resolution Fourier transform mass spectrometry-based proteomics technology. In-depth proteomic profiling of 30 histologically normal human samples including 17 adult tissues, 7 fetal tissues and 6 purified primary hematopoietic cells resulted in identification of proteins encoded by greater than 17,000 genes accounting for ~84% of the total annotated protein-coding genes in humans. This large human proteome catalog (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease. The authors request that those considering use of this dataset for commercial purposes contact pandey@jhmi.edu.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: acetylated residue; iodoacetamide derivatized residue; L-methionine sulfoxide
  • Instrument: LTQ Orbitrap Velos; LTQ Orbitrap Elite

Dataset History

VersionDatetimeStatusChangeLog Entry
02013-11-01 02:19:05ID requested
12014-04-24 12:25:37announced
22014-05-30 02:05:50announcedUpdated publication reference for PubMed record(s): 24870542, 24669763.
32014-07-24 03:56:38announcedUpdated project metadata.

Publication List

  1. Pinto SM, Manda SS, Kim MS, Taylor K, Selvan LD, Balakrishnan L, Subbannayya T, Yan F, Prasad TS, Gowda H, Lee C, Hancock WS, Pandey A, Functional annotation of proteome encoded by human chromosome 22. J Proteome Res, 13(6):2749-60(2014) [pubmed]
  2. Kim MS, Pinto SM, Getnet D, Nirujogi RS, Manda SS, Chaerkady R, Madugundu AK, Kelkar DS, Isserlin R, Jain S, Thomas JK, Muthusamy B, Leal-Rojas P, Kumar P, Sahasrabuddhe NA, Balakrishnan L, Advani J, George B, Renuse S, Selvan LD, Patil AH, Nanjappa V, Radhakrishnan A, Prasad S, Subbannayya T, Raju R, Kumar M, Sreenivasamurthy SK, Marimuthu A, Sathe GJ, Chavan S, Datta KK, Subbannayya Y, Sahu A, Yelamanchi SD, Jayaram S, Rajagopalan P, Sharma J, Murthy KR, Syed N, Goel R, Khan AA, Ahmad S, Dey G, Mudgal K, Chatterjee A, Huang TC, Zhong J, Wu X, Shaw PG, Freed D, Zahari MS, Mukherjee KK, Shankar S, Mahadevan A, Lam H, Mitchell CJ, Shankar SK, Satishchandra P, Schroeder JT, Sirdeshmukh R, Maitra A, Leach SD, Drake CG, Halushka MK, Prasad TS, Hruban RH, Kerr CL, Bader GD, Iacobuzio-Donahue CA, Gowda H, Pandey A, A draft map of the human proteome. Nature, 509(7502):575-81(2014) [pubmed]

Keyword List

  1. submitter keyword: human proteome map, LC-MS/MS, proteogenomics

Contact List

    Akhilesh Pandey
    • contact affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 USA
    • contact email: pandey@jhmi.edu
    • lab head:
    Akhilesh Pandey
    • contact affiliation: Johns Hopkins University
    • contact email: pandey@jhmi.edu
    • dataset submitter:

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