PXD000362

PXD000362 is an original dataset announced via ProteomeXchange.

Title	Systems Biology Proteomic Analysis of Cerebral Cavernous Malformation
Description	Cerebral cavernous malformations are vascular anomalies that can cause hemorrhagic stroke. Mutations in genes encoding Krit 1 (CCM1), OSM (CCM2), and PDCD10 (CCM3) proteins cause CCM. A loss in teh expression of any of these CCM proteins disrupts normal cerebral vessel development by disrupting the cytoskeleton and thereby inhibits endothelial tube ofrmation. Examination of cellular changes based on the loss of CCM gene expression may lead to the methods for early detection and prevention of CCM associated hemorrhagic stroke.
HostingRepository	PRIDE
AnnounceDate	2014-12-02
AnnouncementXML	Submission_2014-12-02_00:30:52.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kevin Knagge
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2013-07-24 08:26:54	ID requested
1	2014-06-09 06:26:22	announced
2	2014-07-25 01:25:58	announced	Updated project metadata.
⏵ 3	2014-12-02 00:30:53	announced	Updated project metadata.

Edelmann AR, Schwartz-Baxter S, Dibble CF, Byrd WC, Carlson J, Saldarriaga I, Bencharit S, Systems biology and proteomic analysis of cerebral cavernous malformation. Expert Rev Proteomics, 11(3):395-404(2014) [pubmed]

curator keyword: Biomedical

submitter keyword: Human cerebral cavernous malformation

Kevin Knagge
contact affiliation	Analytical Sciences
contact email	kknagge@dhmri.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/06/PXD000362

PRIDE project URI

• PRIDE
  1. PXD000362
     1. Label: PRIDE project
     2. Name: Systems Biology Proteomic Analysis of Cerebral Cavernous Malformation