PXD000159

PXD000159 is an original dataset announced via ProteomeXchange.

Title	SIRT6 and SIRT7 binding proteome
Description	To find the SIRT6 and SIRT7 binding proteins, we expressed V5-tagged SIRT6 and SIRT7 and pulled down this protein with anti-V5 agarose affinity gel. Sirtuins are a family of NAD-dependent deacetylases which deacetylate not only histones but also a wide range of target proteins. Sirtuins are conserved from yeast to mammal, and are known to regulate many processes such as cellular metabolism, apoptosis, cellular senescence, cell cycle, and organism-level aging. Among the members of sirtuins showing different subcellular localization, SIRT1, SIRT6 and SIRT7 are localized in nucleus. Whereas many functions and interacting proteins of SIRT1 have been studied, functions of SIRT6 and SIRT7 are not extensively revealed yet. Since it is important to understand the molecular function of SIRT6 and SIRT7, we here aimed to identify interacting proteins in mammalian cells. Extra primary submitter: Namgyu Lee, Department of Life Sciences, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea Lab head: Kwan Yong Choi, Department of Life Sciences and Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, 790-784, Republ ic of Korea
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:21:28.829.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dae-Kyum Kim
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue; monohydroxylated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2013-02-26 02:09:24	ID requested
1	2014-04-28 07:17:57	announced
2	2014-05-15 06:10:44	announced	Updated publication reference for PubMed record(s): 24782448.
3	2014-07-25 00:55:16	announced	Updated project metadata.
⏵ 4	2024-10-22 04:21:36	announced	2024-10-22: Updated project metadata.

Lee N, Kim DK, Kim ES, Park SJ, Kwon JH, Shin J, Park SM, Moon YH, Wang HJ, Gho YS, Choi KY, Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging. Proteomics, 14(13-14):1610-22(2014) [pubmed]

10.1002/pmic.201400001;

curator keyword: Biomedical

submitter keyword: SIRT7,SIRT6, LC-MS/MS

Dae-Kyum Kim
contact affiliation	Department of Life Science
contact email	sses162@postech.ac.kr
lab head
Dae-Kyum Kim
contact affiliation	Department of Life Science
contact email	sses162@postech.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/04/PXD000159

PRIDE project URI

• PRIDE
  1. PXD000159
     1. Label: PRIDE project
     2. Name: SIRT6 and SIRT7 binding proteome