PXD000050

PXD000050 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The human islet of Langerhans proteome database
Description	Type 2 diabetes is a worldwide disease reaching epidemic dimensions. The rapid progression of the disease urgently calls for both a broader and deeper understanding of its pathophysiology. In line with this statement, the Human Diabetes Proteome Project (HDPP) was officially launched at the 11th HUPO meeting in Boston, 2012. A special session was dedicated to this new initiative, gathering experts in the main topics related to diabetes and its associated complications. Key issues were debated with a focus on how deranged circulating glucose and free fatty acids induce dysfunction. It has been decided that HDPP will therefore focus on studying the early stages of diabetes that lead to abnormal glucose and lipid levels. The initiative will initially focused on islets of Langerhans, insulin-producing cell lines, and blood human samples from diabetes-related cohorts. In subsequent stages HDPP will investigate target tissues in which glucose and lipids could promote protein dysfunctions. Omics-rooted systems approaches enhanced by bioinformatics will be deployed to unravel effects of lipids and glucose triggering diabetes initiation and progression. A first milestone has been defined for the 12th HUPO meeting in Yokohama, 2013: the 1000 diabetes-associated protein (the 1000-HDPP) database, i.e. a freely available internet resource (www.HDPP.info) of more than 1000 proteins with links to their corresponding proteotypic peptides, affinity reagents and protein-specific biological/biomedical information. Human islets digested and seperated by off-gel electrophoresis. Analysis by LTQ-Orbitrap velos mass spectrometer (fragmentation by CID,gaz phase fractionnation with four m/z windows: 400-520, 515-690, 685-979, 974-2000)
HostingRepository	PRIDE
AnnounceDate	2013-07-23
AnnouncementXML	Submission_2013-09-30_06:21:36.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD000050
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Domitille Schvartz
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No applicable mass modifications
Instrument	orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2012-10-12 02:33:48	ID requested
1	2013-07-23 15:25:33	announced
1	2013-10-07 04:06:50	announced
2	2013-09-27 06:01:19	announced	missing
2	2014-07-28 00:23:54	announced	Updated project metadata.
3	2013-09-27 06:02:05	announced	missing
⏵ 4	2013-09-30 06:21:36	announced	missing

Publication List

F. Topf, D. Schvartz, P. Gaudet, F. Priego-Capote, A. Zufferey, N. Turck, P.-A. Binz, P. Fontana, A. Wiederkehr, F. Finamore, I. Xenarios, D. Goodlett, M. Kussmann, P. Bergsten, J.-C. Sanchez, The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention, Translational Proteomics, Volume 1, Issue 1, 2013, Pages 3-11, ISSN 2212-9634, http://dx.doi.org/10.1016/j.trprot.2013.03.002.

F. Topf, D. Schvartz, P. Gaudet, F. Priego-Capote, A. Zufferey, N. Turck, P.-A. Binz, P. Fontana, A. Wiederkehr, F. Finamore, I. Xenarios, D. Goodlett, M. Kussmann, P. Bergsten, J.-C. Sanchez, The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention, Translational Proteomics, Volume 1, Issue 1, 2013, Pages 3-11, ISSN 2212-9634, http://dx.doi.org/10.1016/j.trprot.2013.03.002.

Keyword List

submitter keyword: human, islets, orbitrap

submitter keyword: human, islets, orbitrap

Contact List

Domitille Schvartz
contact affiliation	structural biology and bioinformatics
contact email	domitille.schvartz@unige.ch
Jean-Charles Sanchez
contact attribute	Jean-Charles.Sanchez@unige.ch
contact affiliation	Geneva University - Department of human protein sciences
contact email	Jean-Charles.Sanchez@unige.ch

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/2013/07/PXD000050

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/2013/07/PXD000050

Repository Record List

[ + ]

PRIDE
1. 27526
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction9_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction9_exp1.3
  5. PublicationRef: pending
2. 27519
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction2_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction2_exp1.3
  5. PublicationRef: pending
3. 27522
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction5_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction5_exp1.3
  5. PublicationRef: pending
4. 27529
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction7_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction7_exp1.3
  5. PublicationRef: pending
5. 27524
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction8_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction8_exp1.3
  5. PublicationRef: pending
6. 27527
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction10_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction10_exp1.3
  5. PublicationRef: pending
7. 27521
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction4_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction4_exp1.3
  5. PublicationRef: pending
8. 27518
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction1_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction1_exp1.3
  5. PublicationRef: pending
9. 27520
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction3_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction3_exp1.3
  5. PublicationRef: pending
10. 27523
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction6_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction6_exp1.3
  5. PublicationRef: pending
11. 27525
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction8_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction8_exp1.3
  5. PublicationRef: pending
12. 27528
  1. InstrumentRef: INSTRUMENT_1
  2. Label: Betajudo N1727_GPF4_merge_fraction12_exp1.3
  3. ModificationList: No applicable mass modifications,
  4. Name: Betajudo N1727_GPF4_merge_fraction12_exp1.3
  5. PublicationRef: pending