This data set contains RAW, and related result files from immunopurification mass-spectrometry experiments run on Orbitrap Lumos instruments from Thermo Fisher. Each biological replicate was done from either HeLa S3, cytoplasm, nuclear extract, or chromatin bound fraction using either DYRK1A or RNF169 as a bait. RAW files are labelled by replicate, cellular fraction, antibody that was used for each DYRK1A immunopurification and date.