PXD016974

PXD016974 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy
Description	Muscle atrophy is a physiological response to disuse and malnutrition, but hibernating bears are largely resistant to this phenomenon. Unlike other mammals, they efficiently reabsorb amino acids from urine, periodically activate muscle contraction, and their adipocytes differentially responds to insulin. The contribution of myocytes to the reduced atrophy remains largely unknown. Here we show how metabolism and atrophy signaling are regulated in skeletal muscle of hibernating grizzly bear.
HostingRepository	MassIVE
AnnounceDate	2020-01-06
AnnouncementXML	Submission_2020-01-06_09:14:35.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Leif Steil
SpeciesList	scientific name: Ursus arctos horribilis; NCBI TaxID: 116960;
ModificationList	iodoacetamide - site C
Instrument	LTQ FT

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-06 08:56:11	ID requested
⏵ 1	2020-01-06 09:14:37	announced

Publication List

Mugahid DA, Sengul TG, You X, Wang Y, Steil L, Bergmann N, Radke MH, Ofenbauer A, Gesell-Salazar M, Balogh A, Kempa S, Tursun B, Robbins CT, V, ö, lker U, Chen W, Nelson L, Gotthardt M, Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy. Sci Rep, 9(1):19976(2019) [pubmed]

Mugahid DA, Sengul TG, You X, Wang Y, Steil L, Bergmann N, Radke MH, Ofenbauer A, Gesell-Salazar M, Balogh A, Kempa S, Tursun B, Robbins CT, V, ö, lker U, Chen W, Nelson L, Gotthardt M, Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy. Sci Rep, 9(1):19976(2019) [pubmed]

Keyword List

submitter keyword: hibernation, grizzly, muscle atrophy

submitter keyword: hibernation, grizzly, muscle atrophy

Contact List

Prof. Uwe Voelker
contact affiliation	Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
contact email	voelker@uni-greifswald.de
lab head
Leif Steil
contact affiliation	university medicine greifswald
contact email	steil@uni-greifswald.de
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084760/